Category: Cell Adhesion

Guide to the extracellular matrix, anchor, and adhesion proteins 2nd Ed

Edited by Thomas Kreis and Ronald Vale (1999), A Sambrook & Tooze Publication At Oxford University press.

Part 1 Cytoskeleton-associated anchor and signal transduction proteins

Introduction

Linkers to actin filaments

  • aciculin
  • alpha-actinins
  • adducin
  • ankryns
  • calpains (EC 3.4.22.17)
  • alpha-catenin
  • cysteine-rich protein family
  • dystrophin/utrophin
  • ERM proteins: ezrin, radixin, and moesin
  • focal adhesion kinase (FAK)
  • paxillin
  • plakoglobin, beta-catenin, and the ARM family
  • ponticulin
  • p58gag
  • p130CAS
  • pp60c-src
  • 43K-rapsyn
  • Rho GTPase family (overview of family)
  • Rho
  • Rac
  • Cdc42
  • spectrins
  • talin
  • tensin
  • VASP
  • vinculin
  • zyxin

Linkers to intermediate filaments

  • desmocalmin
  • desmoplakins
  • pemphigoid antigens
  • plectin

Tight junction proteins

  • cingulin
  • symplekin
  • ZO-1 and ZO-2

Part 2 Cell adhesion and cell-cell contact proteins

  • Introduction
  • The Ig superfamily of adhesion molecules
  • cadherin/catenin-mediated signal transduction
  • signaling via integrins
  • ADAMs
  • cadherins
  • CCAM and other CEA-related CAMs
  • CD2/LFA-2
  • CD44
  • cell surface galactosyltransferase
  • chemokine receptors
  • c-Kit receptor tyrosine kienase – kit ligand/stem cell factor
  • connexins
  • contact site A
  • DCC family
  • dystroglycan
  • beta3-endoxin
  • Ep-CAM (epithelial cell adhesion molecule)
  • fascilin I
  • fascilin II
  • Fascilin III
  • Integrins
  • integrin-associated proteins
  • Intercellular adhesion molecules (ICAMs)
  • glypicans
  • limbic system-associated membrane protein
  • Leucine-rich repeat family
  • LFA-1
  • MAdCAM-1
  • Mannose binding proteins (MBP)
  • MHC class I and II
  • Myelin sheath proteins: Overview, Myellin-associated glycoproteins (MAG), myslin basic protein (MBPs), myelin oligodendrocyte glycoprotein (MOG), peripheral myelin protein 22 (PM22_, protein zero (P0), protelipid proteins (lipophilins)
  • Neural cell adhesion molecule (NCAM)
  • Neural cell recognition molecule F11 (contactin)
  • Neural cell recognition molecule L1
  • Neurofascin
  • Neuroglian
  • Neurotactin
  • Notch/delta/serrate
  • NgCAM-related cell adhesion molecule (NrCAM)
  • Occludin
  • PECAM-1/CD31
  • PH-20
  • Platelet GP Ib-IX-V complex
  • Selectins
  • Selectin ligands
  • sevenless and bride of sevenless
  • syndecans
  • TAG-1/axonin-1
  • TCR/CD3 complexes and the CD4 and CD8 co-receptors
  • tetraspans
  • Unc-5 family
  • VCAM-1
  • V-V-C2-C2-C2 CAMs
  • yeast sexual agglutinins

Part 3 ECMs and their receptors

Introduction

Modules in ECM and adhesion molecules

Proteoglycans

ECM modules

  • aggrecan
  • agrin
  • biglycan (BGN)
  • bone sialoprotein (BSP)
  • cartilage matrix protein
  • Cat-301 proteoglycan
  • cholinesterases
  • collagens: overview of the family, fibrillar collagens, FACIT collagens, short chain collagens, basement membrane collagens, multiplexins, collagen with transmembrane domains – MACITs, other collagen
  • decorin (DCN)
  • egg zona pellucida glycoproteins
  • elastin
  • fibrinogen/fibrin
  • fibromodulin
  • fibronectins
  • fibulins
  • hyaluronan, hyaluronan synthase, and hyaluronan-binding proteins
  • laminins
  • link protein
  • mucins
  • nectinepsin
  • netrins
  • nidogen
  • osteopontin
  • osteoprotegerin
  • perlecan
  • reelin
  • sea urchin ECM molecules
  • semaphorins
  • SPARC (osteonectin, BM40)
  • sponge ECM adhesion proteins
  • tenascins
  • thrombospondins
  • versican
  • vitronectin
  • von Willebrand factor

ECM proteinases

  • ECM proteineases
  • astacin/tolloid proteinases
  • lysosomal proteinases
  • matrix metalloproteinases
  • Collagenase (MMPs 1, 8, 13, and 18)
  • stromelysins 1 and 2 (MMPs 3 and 10)
  • Gelatinases (MMPs 2 and 9)
  • Matrylisin (MMP 7)
  • Membrane-type MMPs (MMPs 14, 15, 16, and 17)
  • Other MMPs (MMPs 11, 12, 19, and 20)
  • Tissue inhibitors of metalloproteinases (TIMPs)
  • Neutrophil elastase and cathepsin G
  • plasminogen
  • plasminogen activator inhibitors
  • tissue-type plasminogen activator (tPA)
  • urokinase-type plasminogen activator (uPA) and its receptor (uPAR)